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KMID : 0604520120380020189
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Journal of the Society of Cosmetic Scientists of Korea
2012 Volume.38 No. 2 p.189 ~ p.195
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Reduction of Local Body Fat Thickness and Stimulation of Fat Cell Lipolysis by Slim813
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Park Mi-Young
Jung Kyoung-Mi
Joo Kyeong-Mi
Kim Youn-Joon
Park Young-Ho
Lim Kyung-Min
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Abstract
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Slim813 is a 2-cyclopentene-1-one oxime derivative with potent anti-inflammatory and anti-photoaging effects. Slim813 inhibited LPS-induced TNF-α production and attenuated UVB-induced MMP1 expression. Here in an attempt to find an unrevealed efficacy of Slim813, we found that Slim813 stimulates lipolysis in a dose-dependent manner by increasing intracellular cAMP level through the elevation of HSL activity in fully differentiated adipocytes. Moreover, topical application of Slim813 for two weeks in human reduced the thickness of subcutaneous fat in arm and thigh regions, implying it could be effectively used in the reduction of unwanted local fat accumulation.
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KEYWORD
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Slim813, 3T3-L1 preadipocytes, hormone sensitive lipase, cyclic adenosine monophosphate, subcutaneous fat
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